Starting a weight loss journey with the help of prescription medications can be life-changing for better health. Hydration is one of the most overlooked but crucial aspects during a weight loss journey, as more people turn to GLP-1 receptor agonists like Mounjaro, Wegovy, or Ozempic.
This blog guides you through practical and science-backed strategies on how to stay hydrated on weight loss medications. Whether you are starting your treatment or are a few weeks into the treatment, proper hydration can help ease side effects and support your overall well-being.
Why Hydration Matters When Taking Weight Loss Medications?
Most of the GLP-1 medications slow gastric emptying and reduce appetite, which can lead to lower fluid intake. Side effects that accompany weight loss injections, such as nausea or gastrointestinal discomfort, may also deter you from drinking enough water.
Staying hydrated is important for:
- Preventing dry mouth and headaches
- Supporting digestive and kidney function
- Avoiding constipation
- Maintaining electrolyte balance
Hydration Tips For Weight Loss Drugs
Dry Mouth on Weight Loss Drugs
Dry mouth occurs due to altered salivary gland function and decreased oral intake. It is a common side effect of GLP-1 agonists like Mounjaro and Wegovy. If not managed, it can increase your risk of dental problems.
In the SURMOUNT-1 trial, participants receiving tirzepatide for weight loss experienced gastrointestinal side effects, as potential contributors to fluid loss and electrolyte imbalance.
Hydration Tip:
Keep a water bottle and keep sipping frequently throughout the day. Avoid drinks that worsen dryness, such as those with high caffeine and alcohol.
Nausea and Dehydration with Semaglutide
Semaglutide-based weight loss medications are well known for causing gastrointestinal side effects, especially during the initial weeks. Side effects like nausea, vomiting and lack of appetite may limit your desire to drink fluids.
Hydration Tip:
Take sips of cold and room-temperature water frequently rather than large gulps. Try taking herbal teas and electrolyte-infused water may be gentler on your stomach.
Hydration and Wegovy
One of the most common questions is regarding how much water you should drink on Wegovy. A good starting point for most adults is around 2 to 2.5 litres (8-10 glasses) of fluids per day. If you are experiencing nausea, constipation or sweating during exercise, you may need more water for proper hydration.
Many clinical trials have reported gastrointestinal side effects as among the most common side effects of GLP-1 receptor agonists, contributing to decreased fluid intake. In the STEP 1 trial, up to 44% participants on semaglutide reported nausea, and 24% reported nausea.
Hydration Tip:
Track your water intake through hydration tracking apps, setting reminders or putting measurements on the water bottle. Drinking a glass of water before meals can also prevent overeating.
Best Electrolyte Drinks For Weight Loss Injections
Water alone may not be enough, especially if you are experiencing frequent nausea, diarrhoea and sweating during exercise. In such a case, your body loses vital electrolytes, and these drinks can help restore sodium, potassium and magnesium levels in your body, preventing symptoms like dizziness, fatigue, or muscle cramps.
When choosing one, look for options that are:
- Low in sugar or sugar-free to avoid unnecessary calorie intake
- Free from artificial colours or additives
- Rich in essential minerals
For example:
- Electrolyte tablets
- Powders dissolved in water
- Coconut water
- Oral rehydration solutions (ORS)
How to Avoid Constipation on Weight Loss Medications?
Constipation is a common side effect of GLP-1 receptor agonists like Wegovy and Mounjaro. These medications slow gastric emptying, leading to reduced bowel movements. Increase your fibre intake along with water. Soluble fibre is found in oats, chia seeds, lentils, apples and berries, which absorbs water and forms a gel-like substance that softens stool. Insoluble fibre is found in whole grains and many vegetables; this adds bulk and helps food pass through the digestive tract more efficiently, supporting regularity.
Additional Tips to Relieve or Prevent Constipation
- Stay well-hydrated: Aim for at least 2 to 2.5 litres of fluid per day, or more if you are physically active.
- Physical activity: Light exercises like walking, yoga, or stretching can stimulate gut motility and help ease digestion.
- Gentle laxative or softener: If lifestyle changes are not working, your healthcare provider may recommend an over-the-counter solution.
- Eat regular meals: Skipping meals can further slow digestion. Balanced meals in small portions help your system to keep running.
- Fibre supplements: If adding fibre through diet is difficult, fibre supplements can be helpful, but taken with plenty of water.
Always check with your pharmacist or prescriber before starting supplements or medications to manage side effects.
Final Thoughts
Staying hydrated on weight loss injections like Mounjaro or Wegovy is not just about drinking water; it is about making hydration part of your daily routine. Staying ahead of water intake on your weight loss journey can ease side effects and help your body function more efficiently.
At Cleckheaton Pharmacy, we’re here to support your health journey, whether it’s through weight loss guidance or travel health services. Speak to our expert team for personalised advice, or visit us to learn more about safe, evidence-based support for your wellness goals.
FAQs
Weight loss injections can cause nausea, vomiting, and dry mouth, which can reduce fluid intake. Some also slow digestion, decreasing the body’s thirst cues and leading to dehydration.
Aim for at least 2 to 2.5 litres daily, but increase this amount if you are exercising, sweating more, or experiencing side effects like vomiting or constipation.
Common signs include: Dry mouth and lips, lightheadedness, fatigue, dark yellow urine and headache.
Water, herbal teas, and electrolyte drinks are ideal. Avoid sugary sodas and caffeinated drinks, as they can worsen dehydration.
